Protein structure prediction from sequence variation
نویسندگان
چکیده
منابع مشابه
Protein 3D Structure Computed from Evolutionary Sequence Variation
The evolutionary trajectory of a protein through sequence space is constrained by its function. Collections of sequence homologs record the outcomes of millions of evolutionary experiments in which the protein evolves according to these constraints. Deciphering the evolutionary record held in these sequences and exploiting it for predictive and engineering purposes presents a formidable challen...
متن کاملComputational Prediction of Protein Secondary Structure from Sequence.
Secondary structure of proteins refers to local and repetitive conformations, such as α-helices and β-strands, which occur in protein structures. Computational prediction of secondary structure from protein sequences has a long history with three generations of predictive methods. This unit summarizes several recent third-generation predictors. We discuss their inputs and outputs, availability,...
متن کاملPrediction of Protein Secondary Structure from PDB Structure Information Based on Sequence Segments Homology Searching
In this paper, a novel method to predict protein secondary structure (e.g., helix, beta-sheet and coil) is described. Our method predicts the secondary structure for a query sequence using a segment-wise similarity search, which finds the most probable secondary structure based on similarities between a set of sequence segments of a query sequence and our segment databases: the segment sequence...
متن کاملGalaxyHomomer: a web server for protein homo-oligomer structure prediction from a monomer sequence or structure
Homo-oligomerization of proteins is abundant in nature, and is often intimately related with the physiological functions of proteins, such as in metabolism, signal transduction or immunity. Information on the homo-oligomer structure is therefore important to obtain a molecular-level understanding of protein functions and their regulation. Currently available web servers predict protein homo-oli...
متن کاملPrediction of temperature factors from protein sequence
Protein flexibility is useful in structural and functional aspect of proteins. We have analyzed the local primary protein sequence features that in combination can predict the B-value of amino acid residues directly from the protein sequence. We have also analyzed the distribution of B-value in different regions of protein three dimensional structures. On an average, the normalized Bvalue decre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2012
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.2419